Evista and Depression

Side effects can occur with the use of Evista, and depression appears to be one of them. However, in clinical studies, almost as many women who were taking a placebo also reported depression, so the risk appears to be slight. If you are taking Evista and depression symptoms occur -- such as trouble sleeping or feelings of worthlessness or guilt -- tell your healthcare provider right away.

 

Is Depression an Evista Side Effect?

There are several possible side effects of Evista® (raloxifene hydrochloride), and depression may be one of them. In clinical studies of Evista, depression was reported in up to 6.4 percent of women taking the drug. However, almost as many (6 percent) women not taking Evista also reported being depressed. Therefore, it seems that Evista only slightly increases the risk of depression.
 

Evista and Depression: What Should I Look For?

Depression is extremely common in society today. Therefore, knowing the symptoms of depression can be helpful.
 
Possible symptoms may include:
 
  • Feelings of hopelessness and pessimism
  • Persistent sad, anxious, or "empty" mood
  • Decreased energy, fatigue, and feeling "slowed down"
  • Feelings of guilt, worthlessness, and helplessness
  • Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex
  • Difficulty concentrating, remembering, and making decisions
  • Restlessness and irritability
  • Insomnia, early-morning awakening, or oversleeping
  • Appetite and/or weight loss or overeating and weight gain
  • Thoughts of death or suicide and suicide attempts
  • Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and chronic pain.
     
Keep in mind that other conditions can share similar symptoms with depression.
 
(Evista and Depression Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;